Formation Of Enzyme Substrate Complex Es Is First Step

Formation of Enzyme-Substrate complex (ES) is the first step in catalysed reactions. Describe the other steps till the formation of product.


Mechanism of Enzymatic Action The catalytic cycle of an enzyme action can be described in the following steps
(i) First, the substrate hinds to the active site of the enzyme.
(ii) The binding of the substrate induces the enzyme to alter its shape, fitting more tightly around the substrate. The formation of the ES complex is essential for catalysis.
E + S —– > ES —— > EP ——- >E+P
(iii) The active site of the enzyme, now in close proximity of the substrate breaks the chemical bonds of the substrate and the new enzyme product complex is formed.
(iv) The enzyme releases the products of the reaction and the free enzyme is ready to bind to another molecule of the substrate and run through the catalytic cycle once again.